Search results for "tissue resident memory cells"

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The Abundance of Tumor-Infiltrating CD8+ Tissue Resident Memory T Lymphocytes Correlates with Patient Survival in Glioblastoma

2022

Glial tumors alone account for 40% of all CNS tumors and present a low survival rate. The tumor microenvironment is a critical regulator of tumor progression and therapeutic effectiveness in glioma. Growing evidence from numerous studies of human solid tumor-infiltrating CD8(+) T cells indicates that tissue-resident memory T cells (TRM) represent a substantial subpopulation of tumor-infiltrating lymphocytes (TILs). Although it is reported that some types of cancer patients with high immune infiltration tend to have better outcomes than patients with low immune infiltration, it seems this does not happen in gliomas. This study aimed to characterize TRMs cells in the glioma tumor microenviron…

Settore MED/04 - Patologia Generaletissue resident memory cellsSettore MED/27 - NeurochirurgiaglioblastomaMedicine (miscellaneous)glioblastoma; tissue resident memory cells; CD8<sup>+</sup> lymphocytes; tumor microenvironmenttumor microenvironmentSettore MED/05 - Patologia ClinicaGeneral Biochemistry Genetics and Molecular BiologyCD8+ lymphocytes

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